Transformation That Lasts.Physician-directed care. Board-certified providers. Medical oversight.
Premier Integrative & Cognitive Institute
Our Vision
To create a world where healing goes deeper than symptom management—where science, compassion, and natural medicine unite to restore clarity, resilience, and purpose.
Our Mission
We are here to help people break free from cycles of pain, trauma, and illness through safe, evidence-based, and integrative care. By blending psychiatry, neuroscience, and natural medicine, we guide patients on a path to real transformation—body, brain, and spirit.
What We Do
We provide a multidisciplinary and innovative approach to brain wellness, merging conventional mental health care with pioneering treatments in psychedelics, cellular medicine, and neurology. Our core services include:
Our mission extends beyond symptom relief — we strive to help each person flourish, integrating cutting-edge science with compassionate, personalized care.
What We Treat
Our treatments support healing, recovery, and transformation across mental health, cognitive health, and whole-body wellness.
Mental Health
Depression, anxiety, PTSD, OCD, bipolar disorder, trauma recovery, treatment-resistant conditions.
Brain Health
Dementia, memory issues, TBI recovery, brain fog, focus and performance challenges.
Our Commitment to Safety
Safe. Secure. Supportive.
At our clinic, your safety, privacy, and well-being are our top priorities. All sessions take place in a private, distraction-free environment that fully complies with Colorado’s legal safety protocols and medical standards.
We are HIPAA-compliant, ensuring that your personal information and health records are handled with the highest level of confidentiality and care.
Our therapies are provided by licensed professionals trained in integrative care, and we use only medicines with certified purity and potency. You can feel confident knowing you're in a legally sound, ethically guided, and deeply supportive space.
Our Practitioners
Lynn Welch Puana, MD
Founder & Medical Director, Premier Integrative & Cognitive Medical Institute
Lynn Welch Puana, MD is the Founder and Medical Director of the Premier Integrative & Cognitive Medical Institute. After more than two decades treating patients with chronic pain, trauma, addiction, and complex medical needs, she became deeply committed to transforming how we approach brain and mental wellness. Her passion for this work grew from both her clinical experience and her father’s missed Parkinson’s diagnosis, which was only recognized after he had already progressed to end stage Alzheimer’s—long past the time when early detection could have changed his outcome.
This experience shaped her core belief: we must care for the brain proactively, with the same commitment we give to heart disease or cancer prevention. She advocates for establishing a baseline of brain health early in adulthood and monitoring it over time—allowing patients to catch changes early, get answers sooner, and preserve the best version of themselves.
Driven by both science and compassion, Dr. Puana designed PICMI around the most advanced diagnostic tools available today, including genomic testing, functional brain mapping, and cellular medicine evaluations. Her goal is to help patients understand, through clear scientific evidence, why they think, feel, and function the way they do—so they can finally begin healing in a real and meaningful way.
Through integrative therapies, cellular medicine, and state-regulated psychedelic-assisted treatments, PICMI offers patients a personalized path toward emotional balance, cognitive strength, and true mental wellness. Dr. Puana’s mission is simple: to care for the whole person, to bring clarity where there has been confusion, and to help every patient build a healthier, stronger, more hopeful version of themselves.
Amir Mahmoud, MSN, MBA, RN, PMHNP-BC
Medical Director | Psychiatric-Mental Health Nurse Practitioner
Amir Mahmoud is a board-certified Psychiatric-Mental Health Nurse Practitioner with advanced training in neuroscience-based psychiatry, integrative medicine, and innovative approaches to mental health care. He holds dual bachelor’s degrees in Psychology and Criminal Justice, along with a Master of Science in Nursing and a Master of Business Administration—reflecting both clinical expertise and healthcare leadership.
With over a decade of diverse healthcare experience spanning emergency services, critical care, trauma systems, and psychiatric medicine, Amir brings a comprehensive perspective to patient care. He evaluates and treats children, adolescents, and adults for conditions including depression, anxiety, ADHD, trauma-related disorders, and mood imbalances. His background in high-acuity settings allows him to recognize complex presentations and coordinate care across specialties, ensuring patients receive safe, effective, and integrated treatment.
Amir blends evidence-based psychiatry with leading-edge neuroscience and integrative therapies. His approach combines medication management, cognitive and behavioral therapies, and mindfulness-based strategies with innovative modalities such as ketamine-assisted therapy, neuromodulation, and peptide-supported mental health optimization. When appropriate, he incorporates emerging technologies—including brain mapping and guided virtual reality meditation—to deepen neuroplasticity and accelerate healing. Known for balancing science with empathy, Amir empowers patients to build resilience, clarity, and sustainable well-being.
Amir is passionate about innovation, clinical excellence, and creating transformative pathways for healing at the intersection of psychiatry, neuroscience, and integrative medicine.
Frequently Asked Questions
- Are psychedelic therapies safe and legal?Yes. Ketamine is FDA-approved and administered under medical supervision. Psilocybin is legal in Colorado in authorized settings.
- How do ketamine and psilocybin treatments work?They activate neuroplasticity, helping the brain rewire itself while easing symptoms of depression, PTSD, and trauma.
- What's included in my first visit?A comprehensive evaluation, personalized treatment plan, and guidance on the best next steps.
- How do peptides and regenerative therapies support mental health?By improving cellular repair, balancing hormones, and reducing inflammation, peptides enhance both physical and emotional resilience.
- Do you offer both in-person and virtual care?Yes — we provide online mental health services throughout Colorado, with select therapies (ketamine, psilocybin, IV) available in-person.
- Do you accept insurance?We’re not an insurance-based practice due to the depth and complexity of the care we provide, which extends beyond what insurance typically covers. Traditional insurance rewards short visits, high patient volume, and limited, code-based treatment plans, while we prioritize time, depth, and clinically driven decisions. Many of our offerings — including functional brain mapping, quantitative EEG analysis, precision cognitive and mental-health programs, integrative protocols, peptide and cellular optimization therapies, psychedelic-adjacent preparation and integration, extended visits, and high-touch follow-up — are not covered by insurance. This approach allows us to deliver comprehensive, root-cause care without the constraints of the traditional insurance model.